SARS-CoV2 Recombinant Proteins

Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 (SARS-CoV2) is turning out to be the worst pandemic in the recent history. According to the Johns Hopkins University COVID19 tracker, worldwide, there are 25.5 million confirmed cases of COVID-19 with more than 850,000 deaths. The United States alone has more than 183,000 deaths with over 6 million confirmed cases of infection as of September 1, 2020.

Structurally, SARS-CoV-2 has four main structural proteins including spike (S) glycoprotein, small envelope (E) glycoprotein, membrane (M) glycoprotein, and nucleocapsid (N) protein, and also several accessory proteins such as main Protease (Mpro) and Papain-like protease (PL-protease).

Alzheimer

Alzheimer's is a chronic neurodegenerative disease and a type of dementia. It affects memory, thinking and behavior. Symptoms eventually grow severe enough to interfere with daily tasks. Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (Aβ) within the brain along with hyperphosphorylated and cleaved forms of the microtubule-associated protein tau. Cerebral deposition of amyloid β peptide (Aβ) is an early and critical feature of Alzheimer's disease. Aβ generation depends on proteolytic cleavage of the amyloid precursor protein.